Surgical Pathology Criteria

Hepatosplenic T Cell Lymphoma

Differential Diagnosis

Hepatosplenic T Cell Lymphoma Non-hepatosplenic T Cell Lymphoma
Involves liver, spleen, marrow Variable
Granzyme B usually negative Granzyme B often positive
Perforin usually negative Perforin often positive
EBV usually negative EBV positive in subset

Hepatosplenic T Cell Lymphoma T Large Granular Lymphocytic Leukemia
Involves liver, spleen, marrow Involves blood and marrow
Granzyme B usually negative Granzyme B positive
Perforin usually negative Perforin positive
Clinically aggressive Clinically indolent

Hepatosplenic T Cell Lymphoma Mucosa / Skin Associated T Cell Lymphoma
Predominantly involves liver and spleen Involves mucosa and/or skin but does not predominantly involve liver or spleen
Frequently involves marrow Usually does not involve marrow
Immunophenotype overlaps and morphology of both is variable

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