Enteropathy-Type T Cell Lymphoma
Differential Diagnosis
- Extranodal NK/T cell lymphoma
- Anaplastic large cell lymphoma
- Extranodal marginal zone lymphoma
- Ulcerative jejunoileitis
| Extranodal NK/T Cell Lymphoma | Enteropathy Type T Cell Lymphoma |
|---|---|
| CD56 100% | CD56 20% |
| EBV 100% in nasal sites but variable in other sites and outside endemic areas | EBV variable, possibly by geography |
| No adjacent enteropathy | Adjacent enteropathy 75% |
| Primary Systemic Anaplastic Large Cell Lymphoma | Enteropathy Type T Cell Lymphoma |
|---|---|
| Large anaplastic cells | Wide variety of histologic appearances |
| No adjacent enteropathy | Adjacent enteropathy 75% |
| ALK 85% | ALK negative |
| CD56 negative | CD56 20% |
| Extranodal Marginal Zone Lymphoma | Enteropathy Type T Cell Lymphoma |
|---|---|
| Generally predominantly small cell pattern | Wide variety of patterns |
| B lineage | T lineage |
| Enteropathy-type T Cell Lymphoma | Ulcerative Jejunoileitis |
| Identification of a monomorphic population of atypical T cells | Lacks a monomorphic population |
- Clonal T cell populations are present in both
- Some believe that ulcerative jejunoileitis is an early form of enteropathy-type T cell lymphoma
