Surgical Pathology Criteria

Enteropathy-Type T Cell Lymphoma

Differential Diagnosis

Extranodal NK/T Cell Lymphoma Enteropathy Type T Cell Lymphoma
CD56 100% CD56 20%
EBV 100% in nasal sites but variable in other sites and outside endemic areas EBV variable, possibly by geography
No adjacent enteropathy Adjacent enteropathy 75%
Both may involve the GI tract and both express cytotoxic T markers

Primary Systemic Anaplastic Large Cell Lymphoma Enteropathy Type T Cell Lymphoma
Large anaplastic cells Wide variety of histologic appearances
No adjacent enteropathy Adjacent enteropathy 75%
ALK 85% ALK negative
CD56 negative CD56 20%
Both may involve the GI tract, both may express CD30 and EMA

Extranodal Marginal Zone Lymphoma Enteropathy Type T Cell Lymphoma
Generally predominantly small cell pattern Wide variety of patterns
B lineage T lineage
Both may involve the GI tract

Enteropathy-type T Cell Lymphoma Ulcerative Jejunoileitis
Identification of a monomorphic population of atypical T cells Lacks a monomorphic population

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