Neuroblastoma, Ganglioneuroblastoma and Ganglioneuroma
Supplemental Studies
Immunohistology
| Synaptophysin |
pos |
| NB84 |
pos |
| Tyrosine hydroxylase |
pos |
| Neuron specifc enolase |
pos |
| CD45RB, B and T cell markers |
neg |
| Desmin, Myogenin, MyoD1 |
neg |
| Keratin, HMB45, S100, WT1, CD99 |
neg |
S100 stains Schwannian stroma but not neuroblastoma cells
Genetic Study
- MYCN oncogene amplification
- May be assessed by PCR or fluorescence in situ hybridization (FISH)
- In general, patients with MYCN amplified tumors have a worse prognosis
