Leiomyosarcoma Arising in Vessels
Supplemental Studies
Immunohistology
- Smooth muscle actin and muscle specific actin positive
- Desmin or caldesmon positive but may be less extensive than actin
- Keratin aind EMA may show occasional, usually patchy or dot-like staining
- S100 has been reported in smooth muscle tumors of various sites
- The combination of actin negative and S100 positive should strongly suggest nerve sheath tumor
- CD34 is occasionally positive, usually weakly
