Synovial Sarcoma
Clinical
- Occurs primarily in teenagers and young adults
- Most in extremities or adjacent trunk
- May involve hands and feet
- Actual joint involvement is rare
- Other locations include
- Retroperitoneum and mediastinum
- Lung and pleura
- Kidney
- Heart
- Stomach
- May metastasize to lymph nodes
- Survival
- Size (over 5 cm) is primary predictor of metastasis and survival
- No significant difference between biphasic and monophasic
- Poorly differentiated areas indicates worse behavior
- Two low-power fields or 20% by area cutoffs proposed
- Increased recurrence, metastasis, death
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