Surgical Pathology Criteria

Superficial Angiomyxoma

Differential Diagnosis

 

Superficial angiomyxoma may be located in the perineum and external genitalia and thus confused with the first four lesions below.

Superficial Angiomyxoma Aggressive Angiomyxoma
Usually <5 cm Nearly always >5 cm
Superficial Deep seated
Long thin walled vessels Medium to large thick walled vessels
Desmin negative Desmin positive
Stromal neutrophils No stromal neutrophils

 

Superficial Angiomyxoma Angiomyofibroblastoma
Long thin walled vessels Numerous capillaries and venules
Desmin negative Desmin positive
Stromal neutrophils No stromal neutrophils

 

Superficial Angiomyxoma Cellular Angiofibroma
Long thin walled vessels Hyalinized round vessels
Stromal neutrophils Usually stromal lymphocytes

 

Superficial Angiomyxoma Superficial Myofibroblastoma
Mean age 20 years for perineal lesions Most 40-70's
Long thin walled vessels Inconspicuous vessels
Desmin, ER, PR negative Desmin, ER, PR positive
S100 variable S100 negative
Stromal neutrophils No stromal neutrophils
Frequently multinodular Single nodule
Frequently involves subcutis Superficial
Paucicellular Cellular areas

 

Focal Cutaneous Mucinosis Superficial Angiomyxoma
Poorly circumscribed Circumscribed
Few blood vessels Prominent vascular component
Neutrophils uncommon Neutrophils common
Epithelial component rare Frequent epithelial component

 

Myxoid Neurofibroma Superfical Angiomyxoma
Poorly circumscribed Circumscribed
Uniformly S100 positive S100 variable
Intralesional axons No intralesoinal nerve
No epithelial component May have epithelial component

 

Neurothekeoma Superfical Angiomyxoma
Vessels not prominent Prominent vessels
S100 negative S100 variable
Neutrophils infrequent Frequent neutrophils
No epithelial component May have epithelial component
May contain nerve twigs No intralesional nerve fibers
Frequent epithelioid component Lacks epithelioid component

 

Superficial Acral Fibromyxoma Superficial Angiomyxoma
Neutrophils uncommon Neutrophils common
Epithelial component rare Frequent epithelial component
Prominent fibrous component mixed/alternating with moderately cellular myxoid areas Predominant hypocellular myxoid component, frequently in pools
EMA variably positive EMA negative

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