Surgical Pathology Criteria

Ossifying Fibromyxoid Tumor

Supplemental Studies

Immunohistology

  Four Largest Series Including Other Reports
S100 60-94% 60-94%
Desmin 10-50% 10 to 50%
Smooth muscle actin 0-5% 2 to 50%
GFAP 7% 7-40%
CD57 not tested 60%
NSE not tested 60%
Keratin 5-13% 0-13%
EMA 0-2% 0-2%
Neurofilament 90% negative
MUC4 12% not tested
Data for benign tumors from four largest series: Enzinger 1989, Folpe 2003, Miettinen 2008, Graham 2011
Malignant tumors are reported more frequently positive for keratin, EMA and smooth muscle actin and less frequently positive for S100 and desmin (Graham 2011)

INI1 staining shows a mosaic pattern with loss of expression in 30-60% of cells in 74% of cases (Graham 2011)

Genetic study

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