Surgical Pathology Criteria

Ossifying Fibromyxoid Tumor

Differential Diagnosis

Osteosarcoma Ossifying Fibromyxoid Tumor
Cytologic atypia Bland cytology
Tumor of bone Most are superficial and small
Atypical "tumor" bone Normal appearing lamellar bone

 

Glomus Tumor Ossifying Fibromyxoid Tumor
No ossification Frequent ossification
Actin positive, S100 negative Actin variable, most are S100 positive

 

Myxoid Chondrosarcoma Ossifying Fibromyxoid Tumor
No peripheral ossification Frequent peripheral ossification
Most are deep and large Most are superficial and small
PAS positive PAS negative

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