Epithelioid Sarcoma
Supplemental Studies
Immunohistology
- CD34 50%
- Keratin 95%
- Low molecular weight keratin CK8 is positive in 95%
- High molecular weight keratins rare to 50%
- CK7 22% and CK20 0-15%
- INI1 loss in 91%
| EMA | 95% |
| Vimentin | >95% |
| CA125 | 90% |
| Actin (MSA or SMA) | 30-40% |
| Desmin | 15-70% |
| S100 | Rare |
| CD31 | Negative |
| Factor VIII | Negative |
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Higher rate of desmin reactivity reported in proximal type disease
Genetic study
Loss of heterozygosity on chromosome 22 has been detected in some cases
