Clear Cell Sarcoma
Supplemental Studies
Immunohistology
- Melanocytic markers positive, but some reports suggest less frequently than melanomas
| S100 |
70-100% |
| HMB45 |
70-97% |
| Mitf |
70-80% |
| MelanA |
40-70% |
| bcl2 |
93% |
| EMA |
36% |
| CD117 |
0-15% |
| CD34 |
0-9% |
- Keratin: Negative (one report of 30% positive)
- Actin, desmin: Negative
Genetic analysis
- t(12;22)(q13;q12) identified in 75-90% of cases tested
- t(2;22)(q34;q12) identified in a minority of cases
- Preferentially seen in cases arising in the lower GI tract
- Both involve EWS gene involved in PNETs
- These translocations not identified in melanomas but are found in angiomatoid fibrous histiocytomas
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