Surgical Pathology Criteria–

Cellular Myxoma

Differential Diagnosis

Cellular Myxoma Aggressive Angiomyxoma
Frequently on extremities Perineal or pelvic
Medium to large vessels infrequent Prominent medium to large vessels

Myxoid Neurofibroma Cellular Myxoma
May involve nerve No nerve involvement
S100 positive S100 negative

Low Grade Fibromyxoid Sarcoma Cellular Myxoma
Alternating fibrous and myxoid patterns Uniform myxoid pattern
Swirling, whorled pattern No swirling, whorled pattern

Myxoid Liposarcoma Cellular Myxoma
Arborizing vascular pattern Capillaries may be arching but lack well developed arborizing, chickenwire pattern
Lipoblasts present, usually signet ring type No lipoblasts

Myxofibrosarcoma Cellular Myxoma
Pleomorphism present Uniformly small bland cells
Mitotic figures may be present Mitotic figures rare
May have perivascular increase in cellularity No perivascular increase in cellularity

Cellular Myxoma Intramuscular Myxoma
Moderate cellularity must comprise at least 20% of lesion Markedly hypocellular
Arching vessels may be present Markedly hypovascular
May have areas of collagenous stroma Uniformly myxoid stroma

Juxta-articular Myxoma Cellular Myxoma
Adjacent to large joint Not adjacent to large joint
Histologically these may be identical; they both have a potential to recur

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