Surgical Pathology Criteria

Soft Tissue Giant Cell Tumor of Low Malignant Potential

Differential Diagnosis

Giant Cell Malignant Fibrous Histiocytoma Soft Tissue Giant Cell Tumor of Low Malignant Potential
Marked cytologic atypia in mononuclear cell component Mild atypia at most
Coagulative tumor cell necrosis frequently present Coagulative necrosis not permitted
Atypical mitotic figures frequently found Atypical mitotic figures not permitted

 

Tenosynovial Giant Cell Tumor Soft Tissue Giant Cell Tumor of Low Malignant Potential
Usually located near joints Wide variety of locations
Usually low mitotic rate Frequently high mitotic rate
Usually polymorphous with siderophages, foam cells and lymphocytes Usually lacks siderophages, foam cells and lymphocytes
Metaplastic bone not seen Metaplastic bone frequent
Usually has hyalinization of stroma Lacks hyaline stroma

 

Soft Tissue Giant Cell Tumor of Low Malignant Potential Plexifiorm Fibrohistiocytic Tumor
Mixed giant and spindled cells but not distinctly biphasic Biphasic with nodules of histiocyte-like cells with giant cells and spindled fibroblastic areas
Infiltrating nodules Plexiform infiltrative pattern
Frequent mitotic figures Mitotic figures rare

 

Extraskeletal Osteosarcoma Soft Tissue Giant Cell Tumor of Low Malignant Potential
Malignant cytologic features Mild atypia at most
Osteoid in a lace-like pattern formed by malignant cells Frequently a rim of metaplastic bone

 

Giant Cell Rich Nodular Fasciitis Soft Tissue Giant Cell Tumor of Low Malignant Potential
Areas of typical nodular fasciitis usually present with loose myxoid stroma and C and S shaped fascicles Lacks areas with appearance of nodular fasciitis
Giant cells frequent in intravascular fasciitis Vascular invasion is frequent but main lesion is not intravascular

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