Sclerosing Epithelioid Fibrosarcoma
Supplemental Studies
Immunohistology
| MUC4 |
78% strong diffuse positive (Doyle 2012) |
| Vimentin |
positive |
| bcl2 |
90% |
| EMA |
7/14 focal weak positive |
| S100 |
4/14 focal weak positive |
| Keratin |
2/14 focal weak positive |
| NSE |
2/14 |
| Smooth muscle actin |
negative |
| Desmin |
negative |
| HMB45 |
negative |
| CD45RB (LCA) |
negative |
| CD68 |
negative |
MUC4 also stains 100% of
low grade fibromyxoid sarcoma
Genetic analysis
- Translocations involving fus t(7;17) and rarely t(11;17) seen in 38% of MUC4 positive cases
