Proliferative Fasciitis
Differential Diagnosis
Proliferative Myositis and
Ischemic Fasciitis differ from
Proliferative Fasciitis only by location and clinical presentation
| Fibromatosis, Abdominal Desmoid and Extra-abdominal Desmoid |
Proliferative Fasciitis |
| No ganglion-like cells |
Ganglion-like cells present |
| Usually >3 cm |
Usually <4 cm |
| Predominantly collagenous |
Predominantly myxoid |
| Almost always involves muscle with degenerating muscle cells at tumor border |
Usually does not involve muscle |
| Ganglioneuroma |
Proliferative Fasciitis |
| Fibrillar background |
Myxoid background with reactive myofibroblasts |
| S100 may stain satellite cells |
S100 negative |
| Malignant Neoplasm, NOS |
Proliferative Fasciitis |
| Cytologically malignant |
Lacks malignant cytologic features |
| Atypical mitotic figures may be present |
No atypical mitotic figures |
| Usually >4 cm |
Usually <4 cm |
| Rhabdomyosarcoma |
Proliferative Fasciitis |
| May have cross-striations |
No cross-striations |
| Cytooplasm typically eosinophilic |
Cytoplasm typically basophilic |
| Desmin, myogenin positive |
Desmin, myogenin negative |
| Cytologically malignant |
Lacks malignant cytologic features |
| Atypical mitotic figures may be present |
No atypical mitotic figures |
| Usually >4 cm |
Usually <4 cm |
