Surgical Pathology Criteria

Proliferative Fasciitis

Differential Diagnosis

Proliferative Myositis and Ischemic Fasciitis differ from Proliferative Fasciitis only by location and clinical presentation

 

Proliferative Fasciitis Nodular Fasciitis
Ganglion-like cells present No ganglion-like cells
Clusters or linear arrangement of small vessels Vessels usually not clustered

 

Fibromatosis, Abdominal Desmoid and Extra-abdominal Desmoid Proliferative Fasciitis
No ganglion-like cells Ganglion-like cells present
Usually >3 cm Usually <4 cm
Predominantly collagenous Predominantly myxoid
Almost always involves muscle with degenerating muscle cells at tumor border Usually does not involve muscle

 

Ganglioneuroma Proliferative Fasciitis
Fibrillar background Myxoid background with reactive myofibroblasts
S100 may stain satellite cells S100 negative

 

Malignant Neoplasm, NOS Proliferative Fasciitis
Cytologically malignant Lacks malignant cytologic features
Atypical mitotic figures may be present No atypical mitotic figures
Usually >4 cm Usually <4 cm

 

Rhabdomyosarcoma Proliferative Fasciitis
May have cross-striations No cross-striations
Cytooplasm typically eosinophilic Cytoplasm typically basophilic
Desmin, myogenin positive Desmin, myogenin negative
Cytologically malignant Lacks malignant cytologic features
Atypical mitotic figures may be present No atypical mitotic figures
Usually >4 cm Usually <4 cm

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