Plexiform Fibrohistiocytic Tumor
Differential Diagnosis
- Dermatofibroma / Dermal fibrous histiocytoma
- Nodular Fasciitis
- Fibrous Hamartoma of Infancy
- Fibromatosis
- Soft Tissue Giant Cell Tumor of Low Malignant Potential
- Dermatofibrosarcoma Protuberans
- Plexiform Neurofibroma
- Myofibroma
- Giant cell fibroblastoma
Dermal and Deep Fibrous Histiocytoma | Plexiform Fibrohistiocytic Tumor |
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No plexiform rays of fibrous tissue extending into fat | Plexiform rays of fibrous tissue extending into fat |
Histiocytes scattered throughout | Nodules of histiocyte-like cells |
Frequent xanthoma cells | Xanthoma cells rare |
Extravasated red blood cells infrequent | Extravasated red blood cells frequent |
Plexiform Fibrohistiocytic Tumor | Nodular Fasciitis |
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More mature collagenous stroma | Loose, immature stroma |
Small, dense nuclei | Vesicular nuclei |
Mitotic figures usually rare | Mitotic figures frequent |
Nodules of histiocytes frequent | Foam cells and histiocytes infrequent |
Plexiform rays of fibrous tissue | Loose C and S shaped bundles of cells |
Fibrous Hamartoma of Infancy | Plexifiorm Fibrohistiocytic Tumor |
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Myxoid stroma | Fibrous stroma |
Foci of immature cells | Nodules of histiocyte-like cells |
No multinucleated cells | Frequent multinucleated cells in nodules |
Fibromatosis, Abdominal Desmoid, Extra-abdominal Desmoid | Plexifiorm Fibrohistiocytic Tumor |
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Diffuse infiltrative pattern | Plexiform and nodular pattern |
No nodules of histiocytes and giant cells | Nodules of histiocyte-like cells and multinucleated giant cells |
Wider, longer fascicles | Shorter fascicles |
Centered in muscle | Centered in subcutis |
Soft Tissue Giant Cell Tumor of Low Malignant Potential | Plexifiorm Fibrohistiocytic Tumor |
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Mixed giant and spindled cells but not distinctly biphasic | Biphasic with nodules of histiocyte-like cells with giant cells and spindled fibroblastic areas |
Infiltrating nodules | Plexiform infiltrative pattern |
Frequent mitotic figures | Mitotic figures rare |
Plexiform Fibrohistiocytic Tumor | Dermatofibrosarcoma Protuberans |
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Ray-like extension into surrounding fat | Infiltrates between and around individual fat cells |
Collagenous stroma | Usually contains only fine collagen |
Nodules of histiocytes and giant cells in most cases | Histiocytes and giant cells very rare |
CD34 negative | CD34 stains lesional cells |
Plexiform Neurofibroma | Plexifiorm Fibrohistiocytic Tumor |
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S100 positive | S100 negative |
No nodules of histiocytes and giant cells | Nodules of histiocyte-like cells and multinucleated giant cells |
Myofibroma | Plexifiorm Fibrohistiocytic Tumor |
---|---|
Circumscribed | Plexiform rays infiltrate fat |
Central primitive dark cells with hemangiopericytoma-like vessels | Nodules with histiocyte-like cells and multinucleated cells |
Plexiform Fibrohistiocytic Tumor | Giant Cell Fibroblastoma |
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Ray-like extension of fibrous tissue into surrounding fat | Infiltrates between and around individual fat cells |
Lacks pseudovascular spaces | Pseudovascular spaces present |
Nodules of histiocytes and giant cells in most cases | Scattered individual giant cells |
CD34 negative | CD34 stains lesional cells |