Palmar Fibromatosis

Clinical

Peak age 60-70 years
- Rare under 20
Most cases palmar
- Rare cases involve dorsum of hand or wrist
Multinodular
May cause contractures
- With or without pain
May be bilateral
May be associated with other fibromatoses
- Plantar fibromatosis in 10-20% of cases
- Penile fibromatosis in 1% of cases
- Knuckle pads
Clinical associations
- Epilepsy
- Diabetes
- Alcohol abuse and cirrhosis
- Smoking
- Manual labor
Predominantly seen in patients of northwest European origin
In some populations may affect as many as 20% of males and 4% of females
Familial predisposition
- Generally appears to be autosomal dominant
Recurrences do occur but are not destructive
- Never metastasizes
- May regress with age