Cases with multiple lesions may be superficial or deep and include more organ involvement
90% <2 years
60% near birth
Rare in adults
Usually on head, neck, upper trunk
May show autosomal dominant inheritance
Rarely associated with congenital defects
0.5 to >7 cm
May be white or purple nodule
May appear to be a scar
May show growth after birth with later stabilization or regression
Individual lesions cured by excision
May not be possible in multifocal cases with visceral involvement
Visceral involvement may cause death
Kempson RL, Fletcher CDM, Evans HL, Henrickson MR, Sibley RS. Tumors of the Soft Tissues, Atlas of Tumor Pathology, AFIP Third Series, Fascicle 30, 2001
Fletcher CDM, Unni KK, Mertens F. Pathology and Genetics of Tumours of Soft Tissue and Bone, World Health Organization Classification of Tumours 2002
Weiss SW, Goldblum JR. Enzinger and Weiss's Soft Tissue Tumors, 5th edition, 2008
Daimaru Y, Hashimoto H, Enjoji M. Myofibromatosis in adults (adult counterpart of infantile myofibromatosis). Am J Surg Pathol 1989 Oct;13(10):859-65.
Fletcher CD, Achu P, Van Noorden S, McKee PH. Infantile myofibromatosis: a light microscopic, histochemical and immunohistochemical study suggesting true smooth muscle differentiation. Histopathology 1987 Mar;11(3):245-58.
Granter SR, Badizadegan K, Fletcher CD. Myofibromatosis in adults, glomangiopericytoma, and myopericytoma: a spectrum of tumors showing perivascular myoid differentiation. Am J Surg Pathol 1998 May;22(5):513-25.
Jennings TA, Duray PH, Collins FS, Sabetta J, Enzinger FM. Infantile myofibromatosis. Evidence for an autosomal-dominant disorder. Am J Surg Pathol 1984 Jul;8(7):529-38.
Bracko M, Cindro L, Golouh R. Familial occurrence of infantile myofibromatosis. Cancer 1992 Mar 1;69(5):1294-9.
Briselli MF, Soule EH, Gilchrist GS. Congenital fibromatosis: report of 18 cases of solitary and 4 cases of multiple tumors. Mayo Clin Proc 1980 Sep;55(9):554-62
Chung EB, Enzinger FM. Infantile myofibromatosis. Cancer 1981 Oct 15;48(8):1807-18.
Mentzel T, Calonje E, Nascimento AG, Fletcher CD. Infantile hemangiopericytoma versus infantile myofibromatosis. Study of a series suggesting a continuous spectrum of infantile myofibroblastic lesions. Am J Surg Pathol 1994 Sep;18(9):922-30.
Speight PM, Dayan D, Fletcher CD. Adult and infantile myofibromatosis: a report of three cases affecting the oral cavity. J Oral Pathol Med 1991 Sep;20(8):380-4.
Hogan SF, Salassa JR. Recurrent adult myofibromatosis. A case report. Am J Clin Pathol 1992 Jun;97(6):810-4.Spraker MK, Stack C, Esterly NB. Congenital generalized fibromatosis: a review of the literature and report of a case associated with porencephaly, hemiatrophy, and cutis marmorata telangiectatica congenita. J Am Acad Dermatol 1984 Feb;10(2 Pt 2):365-71.