Myofibroma, Solitary and Multicentric

Clinical

Location
- Skin, subcutaneous tissue, muscle
  - Bones, organs less common
- Head, neck, trunk most common
- Rarely seen in almost any other site
75% solitary lesions
- Solitary lesions usually superficial
Multiple lesions may be few to >100
- Cases with multiple lesions may be superficial or deep and include more organ involvement
Age
- 90% <2 years
- 60% near birth
- Rare in adults
  - Usually single
  - Usually superficial
  - Infrequent recurrence
  - Usually on head, neck, upper trunk
May show autosomal dominant inheritance
- Rarely associated with congenital defects
Clinical appearance
- 0.5 to >7 cm
- May be white or purple nodule
- May appear to be a scar
May show growth after birth with later stabilization or regression
Individual lesions cured by excision
- May not be possible in multifocal cases with visceral involvement
Visceral involvement may cause death