Surgical Pathology Criteria

Low Grade Fibromyxoid Sarcoma

Supplemental Studies

Immunohistology

MUC4 100% strong diffuse positive (Doyle 2011)
Vimentin positive
Smooth muscle actin occasional focal weak positive
Desmin occasional focal weak positive
Keratin occasional focal weak positive
S100 occasional focal weak positive, may be positive in cells surrounding rosettes
CD34 occasional focal weak positive
EMA occasional focal weak positive
MUC4 also stains 78% of sclerosing epithelioid fibrosarcoma

Genetic analysis

 

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