Ischemic Fasciitis
Differential Diagnosis
- Ischemic Fasciitis shares histologic features with and could be considered a variant of Proliferative Fasciitis
- They are defined by location, association with fat necrosis and clinical presentation.
- Advanced age and location near limb girdles favor ischemic fasciitis
- Young age and location on extremities favor proliferative fasciitis
- Both are benign
| Sarcoma, NOS |
Ischemic Fasciitis |
| Generally more cellular |
Generally less cellular |
| May show clear cytologic malignancy |
No clear cytological malignancy |
| May have atypical mitotic figures |
Atypical mitotic figures rare |
| Fat necrosis uncommon |
Fat necrosis characteristic |
| Epithelioid Sarcoma |
Ischemic Fasciitis |
| Usually extremities of young patient |
Usually shoulder or hip of elderly patient |
| Usually brightly eosinophilic cytoplasm |
Cytoplasm usually basophilic or amphophilic |
| Keratin positive |
Keratin negative |
Both are frequently CD34 positive
| Myxofibrosarcoma |
Ischemic Fasciitis |
| Cytologically atypical to malignant |
No clear cytologic malignancy |
| Frequent atypical mitotic figures |
Atypical mitotic figures rare |
| Fat necrosis and fibrin rare |
Fat necrosis and fibrin characteristic |
| CD34 negative |
May be CD34 positive |
