Inflammatory Myxohyaline Tumor of Distal Extremities
Differential Diagnosis
- Infectious processes or Nonspecific inflammation
- Ganglion cyst
- Superficial acral fibromyxoma
- Juxta-articular myxoma
- Proliferative fasciitis
- Inflammatory myofibroblastic tumor
- Hodgkin lymphoma
- Myxofibrosarcoma
- Atypical lipomatous tumor
- Myxoid liposarcoma
- Pleomorphic liposarcoma
- Epithelioid sarcoma
- Tenosynovial giant cell tumor
Infection or Nonspecific Inflammation | Inflammatory Myxohyaline Tumor of Distal Extremities |
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Lacks large atypical cells | Large atypical cells often with prominent nucleoli |
Culture, stains may be positive | Culture, stains negative for organisms |
Ganglion Cyst | Inflammatory Myxohyaline Tumor of Distal Extremities |
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Lacks large atypical cells | Large atypical cells |
Inflammation variable | Prominent inflammation |
Superficial Acral Fibromyxoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
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Lacks atypical Reed Sternberg like cells | Atypical Reed Sternberg like cells |
Lacks hyaline stroma | Hyaline stroma present |
Lacks inflammatory infiltrate | Inflammatory infitrate present including neutrophils in myxoid areas |
Juxta-articular Myxoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
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Lacks large atypical cells | Large atypical cells |
Large joints involved | Distal extremities |
Paucicellular | Cellular in areas |
Proliferative Fasciitis | Inflammatory Myxohyaline Tumor of Distal Extremities |
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Ganglion-like cells not atypical | Large atypical cells (may also have ganglion-like cells) |
Lacks inflammation | Prominent inflammation |
Inflammatory Myofibroblastic Tumor | Inflammatory Myxohyaline Tumor of Distal Extremities |
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Spindle cells arranged in a fascicular pattern | Spindle cells randomly distributed |
Rare in extremities | Distal extremities |
Hodgkin Lymphoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
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Myxoid stroma rare | Myxoid stroma present |
No cytoplasmic vacuolation | Cytoplasmic vacuolation |
CD15, CD30 positive | CD15, CD30 negative |
Myxofibrosarcoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
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Rare in distal extremities | Distal extremities |
May have frequent mitotic figures | Infrequent mitotic figures |
Infrequent inflammation | Prominent inflammation |
Atypical Lipomatous Tumor | Inflammatory Myxohyaline Tumor of Distal Extremities |
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Mature fat component | No mature fat |
Lipoblasts | No true lipoblasts |
Myxoid Liposarcoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
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Lacks large atypical cells | Large atypical cells |
Plexiform vascular pattern | No plexiform vascular pattern |
Rare in distal extremities | Distal extremities |
May have lipoblasts | No true lipoblasts |
Pleomorphic Liposarcoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
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Very rare on distal extremities | Distal extremities |
Lipoblasts | No true lipoblasts |
Lacks inflammation | Prominent inflammation |
Epithelioid Sarcoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
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Lacks large Reed-Sternberg like atypical cells | Large Reed-Sternberg like atypical cells |
Keratin positive | Keratin variable, weak, focal |
Frequent necrosis | No necrosis |
Myxoid stroma rare | Myxoid stroma |
Tenosynovial Giant Cell Tumor | Inflammatory Myxohyaline Tumor of Distal Extremities |
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Lacks large atypical cells | Large atypical cells |
Inflammation variable | Prominent inflammation |