Inflammatory Myxohyaline Tumor of Distal Extremities
Differential Diagnosis
- Infectious processes or Nonspecific inflammation
- Ganglion cyst
- Superficial acral fibromyxoma
- Juxta-articular myxoma
- Proliferative fasciitis
- Inflammatory myofibroblastic tumor
- Hodgkin lymphoma
- Myxofibrosarcoma
- Atypical lipomatous tumor
- Myxoid liposarcoma
- Pleomorphic liposarcoma
- Epithelioid sarcoma
- Tenosynovial giant cell tumor
| Infection or Nonspecific Inflammation | Inflammatory Myxohyaline Tumor of Distal Extremities |
|---|---|
| Lacks large atypical cells | Large atypical cells often with prominent nucleoli |
| Culture, stains may be positive | Culture, stains negative for organisms |
| Ganglion Cyst | Inflammatory Myxohyaline Tumor of Distal Extremities |
|---|---|
| Lacks large atypical cells | Large atypical cells |
| Inflammation variable | Prominent inflammation |
| Superficial Acral Fibromyxoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
|---|---|
| Lacks atypical Reed Sternberg like cells | Atypical Reed Sternberg like cells |
| Lacks hyaline stroma | Hyaline stroma present |
| Lacks inflammatory infiltrate | Inflammatory infitrate present including neutrophils in myxoid areas |
| Juxta-articular Myxoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
|---|---|
| Lacks large atypical cells | Large atypical cells |
| Large joints involved | Distal extremities |
| Paucicellular | Cellular in areas |
| Proliferative Fasciitis | Inflammatory Myxohyaline Tumor of Distal Extremities |
|---|---|
| Ganglion-like cells not atypical | Large atypical cells (may also have ganglion-like cells) |
| Lacks inflammation | Prominent inflammation |
| Inflammatory Myofibroblastic Tumor | Inflammatory Myxohyaline Tumor of Distal Extremities |
|---|---|
| Spindle cells arranged in a fascicular pattern | Spindle cells randomly distributed |
| Rare in extremities | Distal extremities |
| Hodgkin Lymphoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
|---|---|
| Myxoid stroma rare | Myxoid stroma present |
| No cytoplasmic vacuolation | Cytoplasmic vacuolation |
| CD15, CD30 positive | CD15, CD30 negative |
| Myxofibrosarcoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
|---|---|
| Rare in distal extremities | Distal extremities |
| May have frequent mitotic figures | Infrequent mitotic figures |
| Infrequent inflammation | Prominent inflammation |
| Atypical Lipomatous Tumor | Inflammatory Myxohyaline Tumor of Distal Extremities |
|---|---|
| Mature fat component | No mature fat |
| Lipoblasts | No true lipoblasts |
| Myxoid Liposarcoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
|---|---|
| Lacks large atypical cells | Large atypical cells |
| Plexiform vascular pattern | No plexiform vascular pattern |
| Rare in distal extremities | Distal extremities |
| May have lipoblasts | No true lipoblasts |
| Pleomorphic Liposarcoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
|---|---|
| Very rare on distal extremities | Distal extremities |
| Lipoblasts | No true lipoblasts |
| Lacks inflammation | Prominent inflammation |
| Epithelioid Sarcoma | Inflammatory Myxohyaline Tumor of Distal Extremities |
|---|---|
| Lacks large Reed-Sternberg like atypical cells | Large Reed-Sternberg like atypical cells |
| Keratin positive | Keratin variable, weak, focal |
| Frequent necrosis | No necrosis |
| Myxoid stroma rare | Myxoid stroma |
| Tenosynovial Giant Cell Tumor | Inflammatory Myxohyaline Tumor of Distal Extremities |
|---|---|
| Lacks large atypical cells | Large atypical cells |
| Inflammation variable | Prominent inflammation |
