Surgical Pathology Criteria

Inflammatory Myxohyaline Tumor of Distal Extremities

Differential Diagnosis

Infection or Nonspecific Inflammation Inflammatory Myxohyaline Tumor of Distal Extremities
Lacks large atypical cells Large atypical cells often with prominent nucleoli
Culture, stains may be positive Culture, stains negative for organisms

 

Ganglion Cyst Inflammatory Myxohyaline Tumor of Distal Extremities
Lacks large atypical cells Large atypical cells
Inflammation variable Prominent inflammation

 

Superficial Acral Fibromyxoma Inflammatory Myxohyaline Tumor of Distal Extremities
Lacks atypical Reed Sternberg like cells Atypical Reed Sternberg like cells
Lacks hyaline stroma Hyaline stroma present
Lacks inflammatory infiltrate Inflammatory infitrate present including neutrophils in myxoid areas

 

Juxta-articular Myxoma Inflammatory Myxohyaline Tumor of Distal Extremities
Lacks large atypical cells Large atypical cells
Large joints involved Distal extremities
Paucicellular Cellular in areas

 

Proliferative Fasciitis Inflammatory Myxohyaline Tumor of Distal Extremities
Ganglion-like cells not atypical Large atypical cells (may also have ganglion-like cells)
Lacks inflammation Prominent inflammation

 

Inflammatory Myofibroblastic Tumor Inflammatory Myxohyaline Tumor of Distal Extremities
Spindle cells arranged in a fascicular pattern Spindle cells randomly distributed
Rare in extremities Distal extremities

 

Hodgkin Lymphoma Inflammatory Myxohyaline Tumor of Distal Extremities
Myxoid stroma rare Myxoid stroma present
No cytoplasmic vacuolation Cytoplasmic vacuolation
CD15, CD30 positive CD15, CD30 negative

 

Myxofibrosarcoma Inflammatory Myxohyaline Tumor of Distal Extremities
Rare in distal extremities Distal extremities
May have frequent mitotic figures Infrequent mitotic figures
Infrequent inflammation Prominent inflammation

 

Atypical Lipomatous Tumor Inflammatory Myxohyaline Tumor of Distal Extremities
Mature fat component No mature fat
Lipoblasts No true lipoblasts

 

Myxoid Liposarcoma Inflammatory Myxohyaline Tumor of Distal Extremities
Lacks large atypical cells Large atypical cells
Plexiform vascular pattern No plexiform vascular pattern
Rare in distal extremities Distal extremities
May have lipoblasts No true lipoblasts

 

Pleomorphic Liposarcoma Inflammatory Myxohyaline Tumor of Distal Extremities
Very rare on distal extremities Distal extremities
Lipoblasts No true lipoblasts
Lacks inflammation Prominent inflammation

 

Epithelioid Sarcoma Inflammatory Myxohyaline Tumor of Distal Extremities
Lacks large Reed-Sternberg like atypical cells Large Reed-Sternberg like atypical cells
Keratin positive Keratin variable, weak, focal
Frequent necrosis No necrosis
Myxoid stroma rare Myxoid stroma

 

Tenosynovial Giant Cell Tumor Inflammatory Myxohyaline Tumor of Distal Extremities
Lacks large atypical cells Large atypical cells
Inflammation variable Prominent inflammation

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