Inflammatory Myofibroblastic Tumor
Supplemental Studies
Immunohistology
| Smooth muscle actin |
>90% positive |
| Vimentin |
>90% positive |
| Factor XIIIa |
positive, extensive |
| Desmin |
10-70% |
| Keratin |
30-77% |
| ALK |
35-60% |
| CD68 |
variable |
| CD34 |
variable |
| p53 |
8% |
| bcl2 |
37% |
| MDM2 |
100% |
| HHV8 |
negative |
In situ hybridization
- ALK rearrangements 47%
- EBV negative
Cytogenetics
- Complex clonal chromosomal aberrations involving 2p23-24 seen in most cases tested
Laboratory Studies
- Abnormalities may be seen in some cases
- Erythrocyte sedimentation rate elevation
- Thrombocytosis
- Polyclonal hypergammaglobulinemia
- Microcytic anemia
