Desmoplastic Fibroblastoma
Differential Diagnosis
- Desmoid fibromatosis
- Fibroma of tendon sheath
- Nuchal fibroma
- Calcifying fibrous tumor/pseudotumor
- Nodular fasciitis
- Low grade fibromyxoid sarcoma
| Fibromatosis, Abdominal Desmoid and Extra-abdominal Desmoid | Desmoplastic Fibroblastoma |
|---|---|
| Mild to moderate cellularity | Paucicellular |
| Moderate vascularity | Hypovascular |
| Extensive infiltration of muscle | Only focal muscle infiltration |
| Spindle cells usually in fascicular pattern | Spindle and stellate cells randomly aranged |
| Desmoplastic Fibroblastoma | Fibroma of Tendon Sheath |
|---|---|
| Wide distribution | Most on hands or wrist |
| Single nodule | Multilobular |
| Hypovascular | Moderately vascular |
| Nuchal-type Fibroma | Desmoplastic Fibroblastoma |
|---|---|
| Small cells with small nuclei | Large cells with large nuclei |
| Poorly circumscribed | Grossly well circumscribed |
| Desmoplastic Fibroblastoma | Calcifying Fibrous Pseudotumor |
|---|---|
| No calcification | Calcification present |
| Large stellate cells | Small spindled cells |
| Inflammation uncommon | Chronic inflammation present |
| Desmoplastic Fibroblastoma | Nodular Fasciitis, Hyalinized |
|---|---|
| Paucicellular | Moderately cellular areas |
| No mucin | Cystic mucin pools, tissue tears |
| Lacks S and C shaped bundles of cells | S and C shaped bundles of cells |
| Mitotic figures absent or rare | Mitotic figures may be numerous |
| Low Grade Fibromyxoid Sarcoma | Desmoplastic Fibroblastoma |
|---|---|
| Moderately cellular | Paucicellular |
| Small nuclei, dense chromatin | Large vesicular nuclei |
| Myxoid areas | No myxoid areas |
| Whorled pattern | No pattern |
