Surgical Pathology Criteria

Calcifying Fibrous Pseudotumor

Differential Diagnosis

Desmoplastic Fibroblastoma Calcifying Fibrous Pseudotumor
No calcification Calcification present
Large stellate cells Small spindled cells
Inflammation uncommon Chronic inflammation present

 

Calcifying Aponeurotic Fibroma Calcifying Fibrous Pseudotumor
Cellular lesion Paucicellular
Frequent chondroid stroma No chondroid stroma
Restricted to hands and feet Widely distributed
Broader areas of calcification Focal small calcifications

 

Fibroma of Tendon Sheath Calcifying Fibrous Pseudotumor
No calcification Calcification present
Inflammation uncommon Chronic inflammation present
Primarily located on digits Widely distributed
Slit-like vessels frequent Lacks slit-like vessels

 

Fibromatosis, Abdominal Desmoid and Extra-abdominal Desmoid Calcifying Fibrous Pseudotumor
Nearly always has cellular areas Uniformly paucicellular
Infiltrative pattern prominent Microscopically infiltrative at most
No calcification Calcification present
Inflammation uncommon Chronic inflammation present

 

Solitary Fibrous Tumor Calcifying Fibrous Pseudotumor
Frequently has cellular areas Uniformly paucicellular
Frequently has stag horn vessels Lacks prominent vascularity
No calcification Calcification present
Inflammation uncommon Chronic inflammation present

 

Calcifying Fibrous Pseudotumor GIST (spindled, bland)
Calcification frequently psammomatous Calcification dystrophic, not psammomatous
Patchy chronic inflammation Inflammation not typical
May form multinodular mass Not typically multinodular
Prominent hyalinized stroma Stroma occasionally sclerotic but not usually hyalinized

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