Calcifying Fibrous Pseudotumor
Differential Diagnosis
- Desmoplastic fibroblastoma / collagenous fibroma
- Calcifying aponeurotic fibroma
- Fibroma of tendon sheath
- Desmoid
- Solitary fibrous tumor
- Gastrointestinal stromal tumor
| Desmoplastic Fibroblastoma | Calcifying Fibrous Pseudotumor |
|---|---|
| No calcification | Calcification present |
| Large stellate cells | Small spindled cells |
| Inflammation uncommon | Chronic inflammation present |
| Calcifying Aponeurotic Fibroma | Calcifying Fibrous Pseudotumor |
|---|---|
| Cellular lesion | Paucicellular |
| Frequent chondroid stroma | No chondroid stroma |
| Restricted to hands and feet | Widely distributed |
| Broader areas of calcification | Focal small calcifications |
| Fibroma of Tendon Sheath | Calcifying Fibrous Pseudotumor |
|---|---|
| No calcification | Calcification present |
| Inflammation uncommon | Chronic inflammation present |
| Primarily located on digits | Widely distributed |
| Slit-like vessels frequent | Lacks slit-like vessels |
| Fibromatosis, Abdominal Desmoid and Extra-abdominal Desmoid | Calcifying Fibrous Pseudotumor |
|---|---|
| Nearly always has cellular areas | Uniformly paucicellular |
| Infiltrative pattern prominent | Microscopically infiltrative at most |
| No calcification | Calcification present |
| Inflammation uncommon | Chronic inflammation present |
| Solitary Fibrous Tumor | Calcifying Fibrous Pseudotumor |
|---|---|
| Frequently has cellular areas | Uniformly paucicellular |
| Frequently has stag horn vessels | Lacks prominent vascularity |
| No calcification | Calcification present |
| Inflammation uncommon | Chronic inflammation present |
| Calcifying Fibrous Pseudotumor | GIST (spindled, bland) |
| Calcification frequently psammomatous | Calcification dystrophic, not psammomatous |
| Patchy chronic inflammation | Inflammation not typical |
| May form multinodular mass | Not typically multinodular |
| Prominent hyalinized stroma | Stroma occasionally sclerotic but not usually hyalinized |
