Surgical Pathology Criteria

Calcifying (Juvenile) Aponeurotic Fibroma

Differential Diagnosis

Fibrous Hamartoma of Infancy Calcifying Aponeurotic Fibroma
Nodules of immature mesenchyme No immature mesenchyme
No palisaded pattern Palisaded cells around nodules
No cartilage or calcification Cartilage and calcification
Never on hands or feet Frequent on hands and feet

 

Infantile Desmoid Fibromatosis Calcifying Aponeurotic Fibroma
Not nodular Nodular
No cartilage or calcification Cartilage and calcification
Usually fat in center of lesion Fat at periphery
Never on hands or feet Frequent on hands and feet

 

Palmar or Plantar Fibromatosis Calcifying Aponeurotic Fibroma
Rare under 20 Predominantly <20
Not calcified Calcified
Rarely chondroid Chondroid
No muscle or nerve infiltration May infiltrate muscle and nerve

 

Chondroma Calcifying Aponeurotic Fibroma
Predominantly adults Predominantly <20
No surrounding epithelioid cells Epithelioid cells around nodules
No muscle or nerve infiltration May infiltrate muscle and nerve

 

Calcifying Aponeurotic Fibroma Calcifying Fibrous Pseudotumor
Cellular lesion Paucicellular
Frequent chondroid stroma No chondroid stroma
Restricted to hands and feet Widely distributed
Broader areas of calcification Focal small calcifications

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