Various sites, more often on extremities and trunk than head and neck
Virtually restricted to head and neck
Lacks xanthoma cells
May have xanthoma cells
Mitotic figures rare but may be atypical
Mitotic figures frequent, many of which are atypical
Nearly always involves sun damaged skin of the elderly
May also occur in irradiated areas
Recurrence rate 0-10%
When strictly defined, metastases virtually never occur
Metastatic cases are probably carcinoma, melanoma or MFH
Kempson RL, Fletcher CDM, Evans HL, Henrickson MR, Sibley RS. Tumors of the Soft Tissues, Atlas of Tumor Pathology, AFIP Third Series, Fascicle 30, 2001
Weiss SW, Goldblum JR. Enzinger and Weiss's Soft Tissue Tumors, 5th edition, 2008
Fretzin DF, Helwig EB. Atypical fibroxanthoma of the skin. A clinicopathologic study of 140 cases. Cancer. 1973 Jun;31(6):1541-52.
Mirza B, Weedon D. Atypical fibroxanthoma: a clinicopathological study of 89 cases. Australas J Dermatol. 2005 Nov;46(4):235-8.
Crowson AN, Carlson-Sweet K, Macinnis C, Taylor JR, Battaglia T, LaMar WL, Minor D, Sutter S, Hill T. Clear cell atypical fibroxanthoma:a clinicopathologic study. J Cutan Pathol. 2002 Jul;29(6):374-81.