Angiomatoid Fibrous Histiocytoma
Supplemental Studies
Immunohistology
| Calponin |
85% |
| Desmin |
50% |
| EMA |
40% |
| CD99 |
50% |
| Smooth muscle actin |
15% |
| Muscle specific actin |
15% |
| H-caldesmon (smooth muscle) |
3% |
| Myoglobin (skeletal muscle) |
Negative |
| Myogenin (skeletal muscle) |
Negative |
| Keratin |
Negative |
| S100 |
Negative |
| CD34, CD31 |
Negative |
| CD45, CD21, CD35 |
Negative |
| CD68 |
0-67% variable reports |
| B,T,Kappa,Lambda |
Mixed in lymphoid component |
Genetic analysis
- Translocations involving EWSR1 or FUS and ATF1 or CREB1 reported in most cases tested
- FISH for EWSR1 has been demonstrated to be positive in 74% of cases
