Surgical Pathology Criteria

Pleomorphic Liposarcoma

Supplemental Studies

Immunohistology

Conventional type

Marker % of Tumors Reported Positive
S100 33-50% lipoblasts only
Smooth muscle actin rare
Desmin rare
EMA neg
CD34 neg
Muscle specific actin 6%
Keratin rare

 

Epithelioid variant
Marker % of Tumors Reported Positive
Vimentin 100%
S100 55% lipoblasts only
Keratin AE1/3 and CAM5.2 38-45% focal
EMA neg
Actin 0-67%
Desmin neg
CD34 neg
Inhibin neg

Immunohistochemistry of lipomatous tumors

  MDM2 CDK4 p16
Atypical lipomatous tumor 45-100% 84-92% 78-97%
Dedifferentiated liposarcoma 55-95 90-100 90
Myxoid / round cell liposarcoma 0-4 0-4 0
Pleomorphic liposarcoma 0 0 0
Lipoma 0-4 0-2 0
Spindle cell and pleomorphic lipoma 0-25 0-6 20
Angiomyolipoma 0 0  
Hibernoma 0 0 positive, variable
Lipoblastoma 0 (1 case) 0 (1 case) positive (1 case)

Genetic analysis

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