Pleomorphic Liposarcoma
Supplemental Studies
Immunohistology
Conventional type
| Marker | % of Tumors Reported Positive |
|---|---|
| S100 | 33-50% lipoblasts only |
| Smooth muscle actin | rare |
| Desmin | rare |
| EMA | neg |
| CD34 | neg |
| Muscle specific actin | 6% |
| Keratin | rare |
Epithelioid variant
| Marker | % of Tumors Reported Positive |
|---|---|
| Vimentin | 100% |
| S100 | 55% lipoblasts only |
| Keratin AE1/3 and CAM5.2 | 38-45% focal |
| EMA | neg |
| Actin | 0-67% |
| Desmin | neg |
| CD34 | neg |
| Inhibin | neg |
Immunohistochemistry of lipomatous tumors
| MDM2 | CDK4 | p16 | |
| Atypical lipomatous tumor | 45-100% | 84-92% | 78-97% |
| Dedifferentiated liposarcoma | 55-95 | 90-100 | 90 |
| Myxoid / round cell liposarcoma | 0-4 | 0-4 | 0 |
| Pleomorphic liposarcoma | 0 | 0 | 0 |
| Lipoma | 0-4 | 0-2 | 0 |
| Spindle cell and pleomorphic lipoma | 0-25 | 0-6 | 20 |
| Angiomyolipoma | 0 | 0 | |
| Hibernoma | 0 | 0 | positive, variable |
| Lipoblastoma | 0 (1 case) | 0 (1 case) | positive (1 case) |
Genetic analysis
- No characteristic cytogenetic abnormalities
- Presence of giant ring chromosomes should suggest the possiblity of a dedifferentiated liposarcoma
- No cytogenetic data available for epithelioid variant
