Pleomorphic Liposarcoma

Differential Diagnosis

Pleomorphic Liposarcoma	Dedifferentiated Liposarcoma
Pleomorphic sarcoma exhibits fatty differentiation	Contains non-lipogenic sarcoma
Cellular pleomorphic sarcoma throughout	Atypical lipomatous areas present
MDM2 and CDK4 negative	MDM2 95% and CDK4 92%

Rare tumors containing both pleomorphic liposarcoma and atypical lipomatous tumor should be designiated as a mixture of the two processes

Pleomorphic Liposarcoma is distinguished from MFH and other pleomorphic non-lipogenic sarcomas by the presence of lipoblasts in the former

Myxoid Liposarcoma does not demonstrate the degree of pleomorphism seen in Pleomorphic Liposarcoma

Epithelioid Variant Pleomorphic Liposarcoma	Carcinoma
Mucin negative large vacuoles	No large vacuoles unless mucin positive
EMA negative	Most are EMA positive
No glandular lumens	May have glandular lumens

Keratin, S100 and vimentin are not useful as both can stain for these markers