Myxoid Liposarcoma
Grading / Staging / Report
Grading is determined by cellularity and designated paucicellular and cellular
- Cellular
- Sheets of back to back uniform cells
- Cells may be larger than in paucicellular areas
- May have more granular chromatin and prominent nucleoli
- Degree of cellularity must be specified
- 25% cellular defined as cellular myxoid liposarcoma
- Associated with significant metastatic potential
French Federation of Cancer Centers System grading scheme for adult sarcomas
- Tumor differentiation score = 2 if paucicellular, 3 if cellular
- Mitotic index
- Score 1 0-9 mitoses per 10 hpf (0.1744 sq mm)
- Score 2 10-19 mitoses per 10 hpf
- Score 3 >19 mitoses per 10 hpf
- Tumor cell necrosis
- Score 0 No necrosis on any slide (one slide per 2 cm tumor diameter)
- Score 1 <50% of tumor is necrotic on slides examined
- Score 2 >50% of tumor is necrotic on slides examined
- Final Grade (add the three scores above)
- Grade 1 Sum of scores = 2 or 3
- Grade 2 Sum of scores = 4 or 5
- Grade 3 Sum of scores = 6 or more
Use TNM Staging
The surgical pathology report should contain or address the following:
- Location
- Type of resection or biopsy
- Histologic diagnosis
- Managerial category III (Local recurrence common; Metastasis occurs)
- Extent of tumor cell necrosis
- Grade
- Paucicellular vs. cellular
- Give percent cellular
- Stage
- Size
- Depth (dermis, subcutis, below fascia, body cavity)
- Margins
- Involved
- Not involved
- If under 2 cm give all such distances and sites
- If over 2 cm give minimum distance and site
- Results of supplementary studies if performed
- Relationship to other specimens from the same patient
- Sheets of back to back uniform cells
- Cells may be larger than in paucicellular areas
- May have more granular chromatin and prominent nucleoli
- Degree of cellularity must be specified
- 25% cellular defined as cellular myxoid liposarcoma
- Associated with significant metastatic potential
- 25% cellular defined as cellular myxoid liposarcoma
- Score 1 0-9 mitoses per 10 hpf (0.1744 sq mm)
- Score 2 10-19 mitoses per 10 hpf
- Score 3 >19 mitoses per 10 hpf
- Score 0 No necrosis on any slide (one slide per 2 cm tumor diameter)
- Score 1 <50% of tumor is necrotic on slides examined
- Score 2 >50% of tumor is necrotic on slides examined
- Grade 1 Sum of scores = 2 or 3
- Grade 2 Sum of scores = 4 or 5
- Grade 3 Sum of scores = 6 or more
- Paucicellular vs. cellular
- Give percent cellular
- Involved
- Not involved
- If under 2 cm give all such distances and sites
- If over 2 cm give minimum distance and site
