- Diffuse or regional overgrowth of fat
- Diffuse or regional overgrowth of mature fat
- Diffuse lipomatosis
- Diffuse overgrowth of mature fat
- Usually involves a large region of an extremity or trunk
- Age usually under 2 years
- Involves muscle and subcutaneous tissue
- Recurs frequently
- Encephalocraniocutaneous lipomatosis
- Haberland syndrome
- Lipomatous hamartomas of the head and face
- Cranial asymmetry and mental retardation
- Neural Fibrolipoma / Fibrolipomatous hamartoma of nerve / lipomatosis of nerve is covered separately
- Surrounds and infiltrates a segment of a major nerve
- Lumbosacral lipoma / lipomatosis
- Diffuse increase in mature fat over lumbosacral spine
- Spina bifida or laminar defect always present
- Meningocele or myelocele may be present
- Usually in infants and children
- May have associated skin tags, hemangioma or hair overgrowth
- Pelvic lipomatosis
- Perivesical and perirectal overgrowth
- Rarely involves retroperitoneum and mesentery
- Frequent cystitis glandularis
- May develop adenocarcinoma
- Usually in black males
- Age 9-80
- Symmetrical lipomatosis
- Madelung or Launois-Bensaude syndrome
- Usually neck, shoulders, upper arms
- Described as pseudoathletic or horse collar
- Frequently associated with diabetes and alcohol abuse
- More common in men of Mediterranean origin
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting/updates: 7/29/07, 11/16/10
- S100 stains mature fat but is seldom of diagnostic use
||Head and face
||Cranial asymmetry, mental retardation
|Fibrolipomatous Hamartoma of Nerve
||Segment of major nerve
||Perivesicular or perirectal
||Neck and shoulders
- May cause problems due to local overgrowth
- May obstruct adjacent structures such as trachea, GI or genitourinary tract
- Many have associated abnormalities
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