Surgical Pathology Criteria

Lipomatosis

Differential Diagnosis

  Distribution Age Associations
Encephalocranial Lipomatosis Head and face Congenital Cranial asymmetry, mental retardation
Diffuse Lipomatosis Regional Infant  
Fibrolipomatous Hamartoma of Nerve Segment of major nerve Usually <30 Macrodactyly
Lumbosacral Lipomatosis Lumbosacral Infant Spina bifida
Pelvic Lipomatosis Perivesicular or perirectal 9-80 Cystitis glandularis
Symmetrical Lipomatosis Neck and shoulders Adult Alcohol, diabetes

Neural Fibrolipoma (Fibrolipomatous Hamartoma of Nerve) Lipofibromatosis
Fat with fibrous component Fat with cellular fibroblastic septa
Centered on and surrounds a major nerve with epineurial and perineurial thickening Soft tissue mass, may surround nerve focally
Frequently associated with macrodactyly Not associated with macrodactyly

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