Surgical Pathology Criteria–

Lipoma

Variant: Intramuscular Lipoma

Diagnostic Criteria

Involves skeletal muscle
Composed of mature adipose tissue
- No cytologic atypia
Most common in extremeties
May be circumscribed or infiltrative
If vascular component is prominent, should be classified as intramuscular hemangioma

Supplemental Studies

Cytogenetic studies show translocations, loss and other aberrations of
- 12q14-15
- 6p21-22
- 13q12-14
- 13q22

Differential Diagnosis

Intramuscular Lipoma	Intermuscular Lipoma
Within skeletal muscle	Between muscles
May be infiltrative or circumscribed	Circumscribed
Recurrence rate 0-20%	Virtually no recurrences

Clinical

Recurrence rate 0-20%
- Lower rate is well excised
- Higher rate if infiltrative
Age 31-76

Bibliography

Bassett MD, Schuetze SM, Disteche C, Norwood TH, Swisshelm K, Chen X, Bruckner J, Conrad EU 3rd, Rubin BP. Deep-seated, well differentiated lipomatous tumors of the chest wall and extremities: the role of cytogenetics in classification and prognostication. Cancer. 2005 Jan 15;103(2):409-16.
Fletcher CD, Martin-Bates E. Intramuscular and intermuscular lipoma: neglected diagnoses. Histopathology. 1988 Mar;12(3):275-87.

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