Lipoma

Variant: Chondroid Lipoma

Cartilaginous Metaplasia in a Lipoma (Chondrolipoma)	Chondroid Lipoma
Contains true hyaline cartilage	No true cartilage

Extraskeletal Myxoid Chondrosarcoma	Chondroid Lipoma
Fibrous septa create lobules	No fibrous septa
No mature fat	Mature fat part of lesion
Cells more uniform	Frequent variation in cell size
t(9;22) or t(9;17)	t(11;16)

Chondroma of Soft Tissue	Chondroid Lipoma
Contains true hyaline cartilage	No true cartilage
No fat component	Mature fat part of lesion
May contain multinucleated giant cells	No multinucleated cells

Myxoid Liposarcoma	Chondroid Lipoma
Plexiform vasculature	No prominent plexiform vasculature
No chondroid matrix	Chondroid matrix
Cells more uniform	Frequent variation in cell size
t(12;16)	t(11;16)

Lipoblastoma	Chondroid Lipoma
Uniform population of lipoblasts	Variable size of vacuolated cells
No chondroid matrix	Chondroid matrix
Restricted to children	Age range 14-75
Deletions of 8q(11-13)	t(11;16)

Ballaux F, Debiec-Rychter M, De Wever I, Sciot R. Chondroid lipoma is characterized by t(11;16)(q13;p12-13). Virchows Arch. 2004 Feb;444(2):208-10.
Gisselsson D, Domanski HA, Hoglund M, Carlen B, Mertens F, Willen H, Mandahl N. Unique cytological features and chromosome aberrations in chondroid lipoma: a case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics. Am J Surg Pathol. 1999 Oct;23(10):1300-4. Erratum in: Am J Surg Pathol 2000 Jan;24(1):165.
Thomson TA, Horsman D, Bainbridge TC. Cytogenetic and cytologic features of chondroid lipoma of soft tissue. Mod Pathol. 1999 Jan;12(1):88-91.
Kindblom LG, Meis-Kindblom JM. Chondroid lipoma: an ultrastructural and immunohistochemical analysis with further observations regarding its differentiation. Hum Pathol. 1995 Jul;26(7):706-15.
Meis JM, Enzinger FM. Chondroid lipoma. A unique tumor simulating liposarcoma and myxoid chondrosarcoma. Am J Surg Pathol. 1993 Nov;17(11):1103-12.