Surgical Pathology Criteria

Lipoma

Variant: Chondroid Lipoma

Diagnostic Criteria

Supplemental Studies

S100 positive
CD68 90%
Keratin 30%
EMA negative
HMB45 negative
Actin negative

Differential Diagnosis

Cartilaginous Metaplasia in a Lipoma (Chondrolipoma) Chondroid Lipoma
Contains true hyaline cartilage No true cartilage

Extraskeletal Myxoid Chondrosarcoma Chondroid Lipoma
Fibrous septa create lobules No fibrous septa
No mature fat Mature fat part of lesion
Cells more uniform Frequent variation in cell size
t(9;22) or t(9;17) t(11;16)

Chondroma of Soft Tissue Chondroid Lipoma
Contains true hyaline cartilage No true cartilage
No fat component Mature fat part of lesion
May contain multinucleated giant cells No multinucleated cells

Myxoid Liposarcoma Chondroid Lipoma
Plexiform vasculature No prominent plexiform vasculature
No chondroid matrix Chondroid matrix
Cells more uniform Frequent variation in cell size
t(12;16) t(11;16)

Lipoblastoma Chondroid Lipoma
Uniform population of lipoblasts Variable size of vacuolated cells
No chondroid matrix Chondroid matrix
Restricted to children Age range 14-75
Deletions of 8q(11-13) t(11;16)

Parachordoma Chondroid Lipoma
No mature fat Mature fat part of lesion
EMA positive EMA negative
Keratin positive Keratin variable
Trisomy 15, monosomy 1, 16, 17 t(11;16)

Clinical

Bibliography

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