Surgical Pathology Criteria

Lipoma

Variant: Angiolipoma

Diagnostic Criteria

Supplemental Studies

Differential Diagnosis

Kaposi Sarcoma Cellular Angiolipoma
Patches, plaques or nodules Subcutaneous nodules
Associated with HIV Associated with typical angiolipomas
Poorly localized Circumscribed
Cytologic atypia No atypia
Slits with red cell extravasation Small vessels with fibrin thrombi

Spindle Cell Hemangioendothelioma Cellular Angiolipoma
Poorly localized Circumscribed
Frequent cavernous vessels Small vessels with fibrin thrombi
Biphasic spindle and epithelioid cells Small vessels and spindle cells
Not associated with typical angiolipomas Frequently associated with typical angiolipomas

Angioleiomyoma Cellular Angiolipoma
Infrequent fat component (but may be seen) Fat component focal but present
Large thick walled vessels Vascular component is predominantly capillaries
No fibrin thrombi Fibrin thrombi

Angiomyolipoma Angiolipoma
Myoid component No myoid component
Large thick walled vessels Vascular component is predominantly capillaries
HMB45 positive HMB45 negative

Clinical

Bibliography

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