Surgical Pathology Criteria

Hibernoma

Supplemental Studies

Immunohistology

S100 85%, may be focal
CD68 Positive
CD34 Negative unless combined with spindle cell lipoma

Immunohistochemistry of lipomatous tumors

  MDM2 CDK4 p16
Atypical lipomatous tumor 45-100% 84-92% 78-97%
Dedifferentiated liposarcoma 55-95 90-100 90
Myxoid / round cell liposarcoma 0-4 0-4 0
Pleomorphic liposarcoma 0 0 0
Lipoma 0-4 0-2 0
Spindle cell and pleomorphic lipoma 0-25 0-6 20
Angiomyolipoma 0 0  
Hibernoma 0 0 positive, variable
Lipoblastoma 0 (1 case) 0 (1 case) positive (1 case)

Genetic Study

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