Hibernoma
Supplemental Studies
Immunohistology
| S100 | 85%, may be focal |
| CD68 | Positive |
| CD34 | Negative unless combined with spindle cell lipoma |
Immunohistochemistry of lipomatous tumors
| MDM2 | CDK4 | p16 | |
| Atypical lipomatous tumor | 60-100% | 84-92% | 83% |
| Dedifferentiated liposarcoma | 95 | 92-100 | |
| Myxoid / round cell liposarcoma | 4 | 4 | |
| Pleomorphic liposarcoma | 0 | 0 | |
| Lipoma | 0-4 | 0 | 0 |
| Spindle cell and pleomorphic lipoma | 0-12 | 0-6 | |
| Angiomyolipoma | 0 | 0 | |
| Hibernoma | 0 | 0 | positive (1 case) |
| Lipoblastoma | 0 (1 case) | 0 (1 case) | positive (1 case) |
Genetic Study
- Frequent rearrangements of 11q13-21 region
