Surgical Pathology Criteria

Dedifferentiated Liposarcoma

Differential Diagnosis

Pleomorphic Liposarcoma Dedifferentiated Liposarcoma
Pleomorphic sarcoma exhibits fatty differentiation Contains non-lipogenic sarcoma
Cellular pleomorphic sarcoma throughout Atypical lipomatous areas present
MDM2 and CDK4 negative MDM2 95% and CDK4 92%
Rare tumors containing both pleomorphic liposarcoma and atypical lipomatous tumor should be designiated as a mixture of the two processes

Lipomatous Hemangiopericytoma Dedifferentiated Liposarcoma
Cytologically bland High grade dedifferentiated areas
No areas of atypical lipomatous tumor Areas or history of atypical lipomatous tumor
Circumscribed Usually non-circumscribed

Independently Arising Nono-lipogenic Sarcoma vs Atypical Lipomatous Tumor

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