Surgical Pathology Criteria

Atypical Lipomatous Tumor

Supplemental Studies

Immunohistology

Immunohistochemistry of lipomatous tumors

  MDM2 CDK4 p16
Atypical lipomatous tumor 45-100% 84-92% 78-97%
Dedifferentiated liposarcoma 55-95 90-100 90
Myxoid / round cell liposarcoma 0-4 0-4 0
Pleomorphic liposarcoma 0 0 0
Lipoma 0-4 0-2 0
Spindle cell and pleomorphic lipoma 0-25 0-6 20
Angiomyolipoma 0 0  
Hibernoma 0 0 positive, variable
Lipoblastoma 0 (1 case) 0 (1 case) positive (1 case)

Genetic analysis

FISH/PCR of lipomatous tumors
  MDM2 FISH MDM2 QPCR CDK4 FISH CDK4 QPCR
Atypical lipomatous tumor 90-100% 72-100% 75-100% 69-100%
Dedifferentiated liposarcoma 100% 100% 100% 100%
Myxoid liposarcoma 20%      
Spindle cell / pleomorphic lipoma Negative Negative Negative Negative
Angiolipoma Negative      
Lipoma, NOS Negative Negative Negative Negative
Sarcomas 0-40% 0% 0% 0%
  • Spindle cell / pleomorphic lipoma showed 89% chromosome 12 polysomy
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