Osteosclerotic Myeloma
Differential Diagnosis
| Osteosclerotic Myeloma |
Myeloma |
Plasmacytoma |
| Osteosclerotic lesion |
Osteolytic lesions |
Osteolytic lesion |
| <5% plasma cells |
usually >> 5% plasma cells |
< 5% plasma cells |
| POEMS syndrome present |
No POEMS syndrome |
No POEMS syndrome |
| Castleman like node changes may be present |
No Castleman changes |
No Castleman changes |
POEMS = Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes
Hematolymphoid Disorders with Marrow Fibrosis (overview)
| Disorder |
Distinguishing Feature(s) |
| Polycythemia Vera, Fibrotic Phase |
History of PV / JAK2+ |
| Essential Thrombocythemia, Fibrotic Phase (rare) |
History of ET / may be JAK2+ |
| CML, Fibrotic Phase |
History of CML / BCR-ABL1+ |
| MDS with Fibrosis |
Dysplastic features in marrow |
| Acute Megakaryoblastic Leukemia |
Blasts, acute onset |
| Osteosclerotic Myeloma |
Plasma cells. light chain restricted |
| Acute Pan-myelosis with Myelofibrosis |
Bone pain, acute onset |
| Primary Myelofibrosis |
Clustered atypical megakaryocytic hyperplasia |
| Hairy cell leukemia |
Clonal B cells |
MDS with Fibrosis = descriptive term that includes primary MDS (often
RAEB2) with fibrosis and therapy related myeloid neoplasms with fibrosis
