Monoclonal Gammopathy of Undetermined Significance
Clinical
Present in approximately 3% of general population over age 50
10% of population over age 80
1-1.5% annual risk of progression to plasma cell or B cell neoplasm
Risk increases with % plasma cells, size of M component, serum free light chain ratio
IgG and IgA MGUS may progress to plasma cell myeloma or primary amyloidosis
IgM MGUS may progress to non-Hodgkin B cell lymphoma, especially lymphoplasmacytic lymphoma or chronic lymphocytic leukemia/small lymphocytic lymphoma, or primary amyloidosis
May also be associated with non-neoplastic conditions including
