Surgical Pathology Criteria

Neural Fibrolipoma

Differential Diagnosis

Neural Fibrolipoma (Fibrolipomatous Hamartoma of Nerve) Lipofibromatosis
Fat with fibrous component Fat with cellular fibroblastic septa
Centered on and surrounds a major nerve with epineurial and perineurial thickening Soft tissue mass, may surround nerve focally
Frequently associated with macrodactyly Not associated with macrodactyly

Neural Fibrolipoma (Fibrolipomatous Hamartoma of Nerve) Lipoma of Nerve Sheath
Centered on and surrounds a major nerve Typically lacks intimate admixture of nervous and adipose tissue
Perineurial thickening Lacks perineural thickening
Frequently associated with macrodactyly Not associated with macrodactyly

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