Well Differentiated Pancreatic Neuroendocrine Tumor / Islet Cell Tumor
Clinical
These names depend on the functional status of the tumor
Defined by clinical plus serologic findings and not by immunohistochemistry
Except for PPoma (see below)
Neoplasms that are positive for a peptide product by immunohistochemistry but lack the corresponding clinical syndrome are designated beta-cell neoplasms, alpha-cell neoplasms etc.
Insulinoma
30-40% of functional tumors
Elevated serum insulin, pro-insulin and C-peptide
Symptoms of hypoglycemia w/ relief after glucose administration
Most insulinomas are benign, but between 5-10% associated with metastasis
