Surgical Pathology Criteria

Squamoid Cyst of Pancreatic Ducts

Differential Diagnosis

Most other cysts are easily distinguished by their non-squamous lining

Lymphoepithelial Cyst of the Pancreas Squamoid Cyst of Pancreatic Ducts
Surrounding dense lymphoid tissue No surrounding lymphoid tissue
Overt keratinization Non-keratinized
Usually peripancreatic Intraductal

Squamoid Cyst of Pancreatic Ducts Dermoid Cyst
No skin appendages or mesenchyme Skin appendages and mesenchyme common
No overt keratinization Keratinized

Epidermoid Cyst in Intrapancreatic Accessory Spleen Squamoid Cyst of Pancreatic Ducts
Surrounded by splenic red pulp Lacks surrounding splenic red pulp
May show overt keratinization Non-keratinized
Involves tail of pancreas Intraductal

Serous Macrocystic / Oligocystic Adenoma Squamoid Cyst of Pancreatic Ducts
Lined by clear cells Lined by squamoid cells
GLUT1 positive GLUT1 at most focally positive

Incidental squamous metaplasia of pancreatic ducts lacks cyst formation

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