Solid Serous Adenoma of the Pancreas

Differential Diagnosis

Serous Microcystic Adenoma	Well Differentiated Pancreatic Neuroendocrine (Islet Cell) Tumor
Synaptophysin and chromogranin negative	Synaptophysin and chromogranin positive

Islet cell tumors may occasionally have clear cytoplasm

Serous Microcystic Adenoma	Solid Serous Adenoma of the Pancreas
Innumerable cysts millimeters in diameter	Solid with spaces at most tenths of millimeters in diameter

Solid and microcystic serous adenoma are composed of histologically identical cells

Solid adenomas may be considered a variant of the microcystic type

Metastatic Renal Cell Carcinoma must be ruled out clinically