Surgical Pathology Criteria

Solid Serous Adenoma of the Pancreas

Differential Diagnosis

Serous Microcystic Adenoma Well Differentiated Pancreatic Neuroendocrine (Islet Cell) Tumor
Synaptophysin and chromogranin negative Synaptophysin and chromogranin positive
  • Islet cell tumors may occasionally have clear cytoplasm
  • Serous Microcystic Adenoma Solid Serous Adenoma of the Pancreas
    Innumerable cysts millimeters in diameter Solid with spaces at most tenths of millimeters in diameter
  • Solid and microcystic serous adenoma are composed of histologically identical cells
  • Solid adenomas may be considered a variant of the microcystic type
  • Metastatic Renal Cell Carcinoma must be ruled out clinically

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