Surgical Pathology Criteria

Solid-pseudopapillary Neoplasm of the Pancreas

Supplemental Studies

Histochemistry

Immunohistology

CD99 paranuclear dots positive
Alpha 1 antitrypsin positive
Alpha 1 antichymotrypsin positive
Neuron specfic enolase positive
Vimentin positive
Progesterone receptor positive
Beta-catenin positive
CD10 positive
CD56 positive
FLI-1 positive
Galectin 3 positive
CD117 positive
Keratin variable
Synaptophysin 50%
CD34 negative
Estrogen receptor negative
Chromogranin negative
  Claudin 5 Claudin 7
Solid Pseudopapillary Tumor Strong membrane positive Membrane negative, occasional cytoplasm

Endocrine Tumor

Membrane negative Membrane positive
Acinar cell carcinoma Membrane negative Membrane positive
Pancreatoblastoma Membrane negative Membrane positive
From Comper 2009

 

Molecular Genetics

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