Pancreatic Intraepithelial Neoplasia
Differential Diagnosis
| Normal Duct |
PanIN |
| Cuboidal to low columnar lining |
Tall columnar lining |
| Amphophilic cytoplasm |
Abundant supranuclear mucin |
| Regular bland nuclei |
May show nuclear crowding and atypia |
| Reactive Duct |
PanIN |
| Round smooth nuclei |
Nuclei may show irregularity |
| Basally oriented nuclei |
May have pseudostratified or stratified nuclei |
| Eosinophilic cytoplasm |
Abundant supranuclear mucin |
| No micropapillary architecture |
May be micropapillary |
| Cancerization of Duct by Invasive Ductal Carcinoma |
PanIN, Grade 3 |
| Abrupt transition of neoplastic to normal |
Gradual transition |
| May be continuous with invasive carcinoma |
Not continuous with invasive carcinoma |
| Intraductal Papillary Mucinous Neoplasm |
PanIN |
| Usually clinically detectable |
Usually not clinically detectable |
| Grossly visible |
Not grossly visible |
| May have well formed papillae |
No well formed papillae |
| May be associated with colloid carcinoma |
No association with colloid carcinoma |
| MUC2 or CDX2 may be positive |
MUC2 and CDX2 negative |
