Surgical Pathology Criteria

Medullary Carcinoma of the Pancreas

Definition

Diagnostic Criteria

Supplemental Studies

Differential Diagnosis

Medullary Carcinoma of the Pancreas Poorly Differentiated Ductal Adenocarcinoma of the Pancreas
Pushing border Infiltrative border
Syncitial pattern Usually has more distinct cell borders
May show microsatellite instability and/or mismatch repair deficiency Not associated with mismatch repair defects
Medullary Carcinoma of the Pancreas Poorly Differentiated Acinar Carcinoma of the Pancreas
Pleomorphic nuclei with variable nucleoli Prominent central nucleoli in most cases
Lipase and trypsin negative Lipase and trypsin positive in most cases
May show microsatellite instability and/or mismatch repair deficiency No mismatch repair defects

Clinical

Classification / Lists

Pancreatic Carcinomas

Bibliography

Author / Update

Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342

Original posting/updates: 1/5/08, 1/5/12

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