Surgical Pathology Criteria

Intraductal Papillary Mucinous Neoplasm of the Pancreas

Differential Diagnosis

Intraductal Papillary Mucinous Neoplasm Mucinous Cystic Neoplasm of the Pancreas
Usually over age 50 Usually under age 50
Male>female Nearly all female
Involves segments of ducts Does not communicate with ducts
Multiple adjacent cystic spaces If multilocular, usually many smaller cysts within a circumscribed larger cyst
Extensive papillae formation Minimal papillae
No ovarian type stroma Ovarian type stroma
May be associated with colloid carcinoma No association with colloid carcinoma

Intraductal Papillary Mucinous Neoplasm PanIN
Usually clinically detectable Usually not clinically detectable
Grossly visible Not grossly visible
May have well formed papillae No well formed papillae
May be associated with colloid carcinoma No association with colloid carcinoma
MUC2 or CDX2 may be positive MUC2 and CDX2 negative

Stanford Medicine Resources:

Footer Links: