Surgical Pathology Criteria

Intraductal Tubular Adenoma of the Pancreas

Differential Diagnosis

Intraductal Tubular Adenoma Intraductal Tubular Carcinoma
Composed of mucin positive pyloric type cells Generally mucin poor or negative
Frequent goblet cells No goblet cells
Low grade atypia High grade atypia
Mitotic rate 1-5/50 hpf Mitotic rate frequently >5/50 hpf
No necrosis Frequent necrosis
Not associated with invasive carcinoma May have associated invasive carcinoma
Intraductal tubular adenoma and carcinoma do not appear to be related

Intraductal Tubular Adenoma Intraductal Papillary Mucinous Neoplasm
Discrete lesion Usually diffuse lesion
Cystic dilation of ducts at tumor site with scant mucin Distended ducts filled with mucin
Tubular pattern Papillary pattern
Low grade atypia Atypia may vary from low to high
MUC2 negative MUC2 positive

Intraductal Tubular Adenoma PanIN
Usually clinically detectable Usually not clinically detectable
Grossly visible Not grossly visible
Well formed tubules No well formed tubules
Low grade atypia Atypia may vary from low to high

Intraductal Tubular Adenoma Mucinous Cystic Neoplasm of the Pancreas
Nodular intraductal growth Mucin filled cyst or cysts
Low grade atypia Atypia may vary from low to high
Males and females affected Nearly all female
Involves segments of ducts Does not communicate with ducts
Extensive tubule formation No tubules
No ovarian type stroma Ovarian type stroma

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