Intraductal Tubular Adenoma of the Pancreas
Differential Diagnosis
| Intraductal Tubular Adenoma |
Intraductal Tubular Carcinoma |
| Composed of mucin positive pyloric type cells |
Generally mucin poor or negative |
| Frequent goblet cells |
No goblet cells |
| Low grade atypia |
High grade atypia |
| Mitotic rate 1-5/50 hpf |
Mitotic rate frequently >5/50 hpf |
| No necrosis |
Frequent necrosis |
| Not associated with invasive carcinoma |
May have associated invasive carcinoma |
Intraductal tubular adenoma and carcinoma do not appear to be related
| Intraductal Tubular Adenoma |
PanIN |
| Usually clinically detectable |
Usually not clinically detectable |
| Grossly visible |
Not grossly visible |
| Well formed tubules |
No well formed tubules |
| Low grade atypia |
Atypia may vary from low to high |
| Intraductal Tubular Adenoma |
Mucinous Cystic Neoplasm of the Pancreas |
| Nodular intraductal growth |
Mucin filled cyst or cysts |
| Low grade atypia |
Atypia may vary from low to high |
| Males and females affected |
Nearly all female |
| Involves segments of ducts |
Does not communicate with ducts |
| Extensive tubule formation |
No tubules |
| No ovarian type stroma |
Ovarian type stroma |
