Surgical Pathology Criteria

Acinar Cell Nodule of the Pancreas

Definition

Alternate/Historical Names

Diagnostic Criteria

Differential Diagnosis

Acinar Cell Nodule of the Pancreas Islet Cell Hyperplasia / Aggregation
Usually prominent nucleoli Salt and pepper chromatin
Trypsin, chymotrypsin, lipase positive Chromogranin, synaptophysin positive
Both are of no clinical significance

Acinar Cell Nodule of the Pancreas Pancreatic Neuroendocrine Microadenoma
Trypsin, chymotrypsin, lipase positive Chromogranin, synaptophysin positive
Usually basal nuclei Usually central nuclei
Usually apical granular eosinophilic cytoplasm Usually scant cytoplasm
Both are of no clinical significance

 

Classification / Lists

Pancreatic Acinar Cell Lesions

Bibliography

Author / Update

Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342

Original posting/last update: 1/9/08, 12/28/13

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